Publications
Selected publications on our C. difficile research
For a full list, see PubMed or Google Scholar
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2025
Cole CG, Zhang ZJ, Dommaraju SR, Dong Q, Pope RL, Son SS, McSpadden EJ, Woodson CK, Lin H, Dylla NP, Sidebottom AM, Sundararajan A, Mitchell DA, Pamer EG. Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance. Cell Host Microbe. 2025 Dec 10;33(12):2100-2114.e6. doi: 10.1016/j.chom.2025.11.007. Epub 2025 Dec 1. PubMed PMID: 41330369; PubMed Central PMCID: PMC12766783.
Nhu NTQ, Lin H, Pigli Y, Sia JK, Kuhn P, Ruppel H, Snitkin ES, Young VB, Kamboj M, Pamer EG, Rice PA, Shen A, Dong Q. Flagellar switch inverted repeats impact heterogeneity in flagellar gene expression and thus C. difficile RT027/MLST1 virulence. Cell Rep. 2025 Jun 24;44(6):115830. doi: 10.1016/j.celrep.2025.115830. Epub 2025 Jun 11. PubMed PMID: 40504685; PubMed Central PMCID: PMC12282940.
Ribis JW, Nieto C, DiBenedetto NV, Mehra A, Kuhn P, Dong Q, Nagawa I, El Meouche I, Aldridge BB, Dunlop MJ, Tamayo R, Singh A, Shen A. Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy. PLoS Pathog. 2025 May;21(5):e1013155. doi: 10.1371/journal.ppat.1013155. eCollection 2025 May. PubMed PMID: 40397889; PubMed Central PMCID: PMC12140426.
Dong Q, Harper S, McSpadden E, Son SS, Allen MM, Lin H, Smith RC, Metcalfe C, Burgo V, Woodson C, Sundararajan A, Rose A, McMillin M, Moran D, Little J, Mullowney MW, Sidebottom AM, Fortier LC, Shen A, Pamer EG. Protection against Clostridioides difficile disease by a naturally avirulent strain. Cell Host Microbe. 2025 Jan 8;33(1):59-70.e4. doi: 10.1016/j.chom.2024.11.003. Epub 2024 Nov 27. PubMed PMID: 39610252; PubMed Central PMCID: PMC11731898.
2023
Dong Q, Lin H, Allen MM, Garneau JR, Sia JK, Smith RC, Haro F, McMillen T, Pope RL, Metcalfe C, Burgo V, Woodson C, Dylla N, Kohout C, Sundararajan A, Snitkin ES, Young VB, Fortier LC, Kamboj M, Pamer EG. Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile. Cell Rep. 2023 Aug 29;42(8):112861. doi: 10.1016/j.celrep.2023.112861. Epub 2023 Jul 30. PubMed PMID: 37523264; PubMed Central PMCID: PMC10627504.
2021
Becattini S, Sorbara MT, Kim SG, Littmann EL, Dong Q, Walsh G, Wright R, Amoretti L, Fontana E, Hohl TM, Pamer EG. Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Cell Host Microbe. 2021 Mar 10;29(3):378-393.e5. doi: 10.1016/j.chom.2021.01.003. Epub 2021 Feb 3. PubMed PMID: 33539766; PubMed Central PMCID: PMC7954923.
2020
Keith JW, Dong Q, Sorbara MT, Becattini S, Sia JK, Gjonbalaj M, Seok R, Leiner IM, Littmann ER, Pamer EG. Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine. Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00362-19. Print 2020 Mar 23. PubMed PMID: 31907198; PubMed Central PMCID: PMC7093144.