Ram Thiyagarajan, Ph.D.

Professional Background

I am focused on unraveling the molecular underpinnings (transcriptomics, proteomics, and metabolomics) of the interactions between immunosenescence (myeloid cells) and neuroinflammation (microglia) and identifying putative diagnostic and prognostic biomarkers for aging, age-related dementia. In addition, I am interested in understanding the interactions of mRNA and miRNA during inflammaging and understanding the role of RNA-binding proteins in age-related neuroinflammation.

• BS, Biochemistry, University of Madras, India
• MS, Medical Physiology, University of Madras, India
• PhD, Medical Physiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
• Other, Biochemistry, University of Buffalo, Buffalo, NY
• Post Doctoral Fellowship, Department of Medicine, Division of Geriatrics and Palliative Medicine, University of Buffalo, Buffalo, NY

• Rajabian Nika, Ikhapoh Izuagie, Shahini Shahryar, Choudhury Debanik, Thiyagarajan Ramkumar, Shahini Aref, Kulczyk Joseph, Breed Kendall, Saha Shilpashree, Mohamed Mohamed Alaa, Udin Susan B, Stablewski Aimee, Seldeen Kenneth, Troen Bruce R, Personius Kirkwood, Andreadis Stelios T. 2023. Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle. Nature Communications, 14 (1). https://doi.org/10.1038/s41467-023-36483-3
• Kwack Kyu Hwan, Zhang Lixia, Kramer Elliot D, Thiyagarajan Ramkumar, Lamb Natalie A, Arao Yukitomo, Bard Jonathan E, Seldeen Kenneth L, Troen Bruce R, Blackshear Perry J, Abrams Scott I, Kirkwood Keith L. 2022. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1002163
• Choudhury Debanik, Rong Na, Ikhapoh Izuagie, Rajabian Nika, Tseropoulos Georgios, Wu Yulun, Mehrotra Pihu, Thiyagarajan Ramkumar, Shahini Aref, Seldeen Kenneth L, Troen Bruce R, Lei Pedro, Andreadis Stelios T. 2022. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells. Cell Reports, 41 (9), 111744. https://doi.org/10.1016/j.celrep.2022.111744
• Shahini Aref, Rajabian Nika, Choudhury Debanik, Shahini Shahryar, Vydiam Kalyan, Nguyen Thy, Kulczyk Joseph, Santarelli Tyler, Ikhapoh Izuagie, Zhang Yali, Wang Jianmin, Liu Song, Stablewski Aimee, Thiyagarajan Ramkumar, Seldeen Kenneth, Troen Bruce R, Peirick Jennifer, Lei Pedro, Andreadis Stelios T. 2021. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo. Science Advances, 7 (36). https://doi.org/10.1126/sciadv.abe5671
• Seldeen Kenneth Ladd, Shahini Aref, Thiyagarajan Ramkumar, Redae Yonas, Leiker Merced, Rajabian Nika, Dynka Andrew, Andreadis Stelios T, Troen Bruce Robert. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors. Nutrition, 87-88, 111189. https://doi.org/10.1016/j.nut.2021.111189
• Seldeen Kenneth Ladd, Redae Yonas Z, Thiyagarajan Ramkumar, Berman Reem Nagi, Leiker Merced Marie, Troen Bruce Robert. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mechanisms of Ageing and Development, 180, 49-62. https://doi.org/10.1016/j.mad.2019.04.001
• Kirkwood Keith L, Zhang Lixia, Thiyagarajan Ramkumar, Seldeen Kenneth L, Troen Bruce R. 2018. Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility. Immunological Investigations, 47 (8), 844-854. https://doi.org/10.1080/08820139.2018.1552360
• Thiyagarajan Ramkumar, Pal Pravati, Pal Gopal Krushna, Subramanian Senthil Kumar, Trakroo Madanmohan, Bobby Zachariah, Das Ashok Kumar. 2015. Additional benefit of yoga to standard lifestyle modification on blood pressure in prehypertensive subjects: a randomized controlled study. Hypertension Research, 38 (1), 48-55. https://doi.org/10.1038/hr.2014.126
• Thiyagarajan Ramkumar, Pal Pravati, Pal Gopal Krushna, Subramanian Senthil Kumar, Bobby Zachariah, Das Ashok Kumar, Trakroo Madanmohan. 2013. Cardiovagal modulation, oxidative stress, and cardiovascular risk factors in prehypertensive subjects: cross-sectional study. American journal of hypertension, 26 (7), 850--857
• Thiyagarajan Ramkumar, Subramanian Senthil Kumar, Sampath Nishanth, Madanmohan Trakroo, Pal Pravati, Bobby Zachariah, Paneerselvam Sankar, Das Ashok Kumar, Manco Melania. 2012. Association between Cardiac Autonomic Function, Oxidative Stress and Inflammatory Response in Impaired Fasting Glucose Subjects: Cross-Sectional Study. PLoS ONE, 7 (7), e41889. https://doi.org/10.1371/journal.pone.0041889