Mihaela Sardiu, PhD

Professional Background

I am a theoretical physicist with extensive experience in molecular modeling, bioinformatics and translational research. My research interests lie in the fields of physics and bioinformatics, which involve developing statistical and computational methods to analyze large-scale biological data and applying these methods to study biological and biomedical problems.

• BS, Physics, University of Bucharest, Bucharest, Romania
• MS, Physics, University of Bucharest, Bucharest, Romania
• PhD, Physics, Florida Atlantic University, Boca Raton, Florida
• Other, Bioinformatics, Stowers Institute for Medical Research, Kansas City , MO

• Data Science, Johns Hopkins Coursera
• SAS Global Certified Professional Directory (SAS9), SAS

• University of Kansas Cancer Center , Member, 2021 - Present

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Research

Overview

My research interest is in the field of quantitative omics data, with a focus on the development of computational methods for processing and extracting biological information from large and complex datasets. One of my aims is to develop new methods for integrative analyses of data across different data types with a goal to identify potentially cancer-related molecular alterations and determine new disease biomarkers. Another priority of mine is to provide a holistic view of merged data and interpretation tools that harmonize biological information across heterogeneous platforms. Lastly, a new focus is on exploring perturbed networks structures and trying to address the dynamics of networks in general using statistical physics principles.

• Zybailov Boris, Mosley AmberL., Sardiu MihaelaE., Coleman MichaelK., Florens Laurence, Washburn MichaelP.. 2006. Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae. JOURNAL OF PROTEOME RESEARCH, 5 (9), 2339-2347
• Sardiu MihaelaE., Cheung MargaretS., Yu Yi-Kuo. 2007. Cysteine-cysteine contact preference leads to target-focusing in protein folding. BIOPHYSICAL JOURNAL, 93 (3), 938-951
• Sardiu MihaelaE., Cai Yong, Jin Jingji, Swanson SeleneK., Conaway RonaldC., Conaway JoanW., Florens Laurence, Washburn MichaelP.. 2008. Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 (5), 1454-1459
• Sardiu MihaelaE., Florens Laurence, Washburn MichaelP.. 2009. Evaluation of Clustering Algorithms for Protein Complex and Protein Interaction Network Assembly. JOURNAL OF PROTEOME RESEARCH, 8 (6), 2944-2952
• Sardiu MihaelaE., Gilmore JoshuaM., Carrozza MichaelJ., Li Bing, Workman JerryL., Florens Laurence, Washburn MichaelP.. 2009. Determining Protein Complex Connectivity Using a Probabilistic Deletion Network Derived from Quantitative Proteomics. PLOS ONE, 4 (10)
• Sardiu MihaelaE., Washburn MichaelP.. 2010. Enriching quantitative proteomics with SIN. NATURE BIOTECHNOLOGY, 28 (1), 40-42
• Fournier MarjorieL., Paulson Ariel, Pavelka Norman, Mosley AmberL., Gaudenz Karin, Bradford WilliamD., Glynn Earl, Li Hua, Sardiu MihaelaE., Fleharty Brian, Seidel Christopher, Florens Laurence, Washburn MichaelP.. 2010. Delayed Correlation of mRNA and Protein Expression in Rapamycin-treated Cells and a Role for Ggc1 in Cellular Sensitivity to Rapamycin. MOLECULAR & CELLULAR PROTEOMICS, 9 (2), 271-284
• Lee KennethK., Sardiu MihaelaE., Swanson SeleneK., Gilmore JoshuaM., Torok Michael, Grant PatrickA., Florens Laurence, Workman JerryL., Washburn MichaelP.. 2011. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. MOLECULAR SYSTEMS BIOLOGY, 7
• Mosley AmberL., Sardiu MihaelaE., Pattenden SamanthaG., Workman JerryL., Florens Laurence, Washburn MichaelP.. 2011. Highly Reproducible Label Free Quantitative Proteomic Analysis of RNA Polymerase Complexes. MOLECULAR & CELLULAR PROTEOMICS, 10 (2)
• Sardiu MihaelaE., Washburn MichaelP.. 2011. Building Protein-Protein Interaction Networks with Proteomics and Informatics Tools. JOURNAL OF BIOLOGICAL CHEMISTRY, 286 (27), 23645-23651