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Lejla Zubcevic, Ph.D.

Lejla Zubcevic portrait
Assistant Professor, Biochemistry and Molecular Biology
lzubcevic@kumc.edu

Professional Background

University of Oxford, Oxford, UK. D.Phil student. Department of Condensed Matter Physics, 2008-2013
Duke University, Durham, North Carolina. Postdoctoral Research Associate, Department of Biochemistry, 2013 - 2019

Interests: Transport across biological membranes, ion channels, biophysics, membrane protein biochemistry, X-ray crystallography, single particle cryo-EM

Education and Training
  • BSc, Biochemistry, University of Copenhagen, Copenhagen, Denmark
  • MSC, Pharmacology, University of Oxford, Oxford, England
  • PhD, Biophysics, University of Oxford, Oxford, England
  • Post Doctoral Fellowship, Ion channels, Structural biology, Duke University, Durham, NC

Research

Overview

Research Interests

The Zubcevic lab is interested in elucidating the molecular mechanisms of transport across biological membranes. We use single particle cryo-EM and X-ray crystallography to study mammalian ion channels and transporters.

Selected Publications
  • Zubcevic Lejla, Lee Seok-Yong. 2019. The role of Ď€-helices in TRP channel gating. Current Opinion in Structural Biology, 58, 314-323. https://doi.org/10.1016/j.sbi.2019.06.011
  • Suo Yang, Wang Zilong, Zubcevic Lejla, Hsu Allen L, He Qianru, Borgnia Mario J, Ji Ru-Rong, Lee Seok-Yong. 2020. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105 (5), 882-894.e5. https://doi.org/10.1016/j.neuron.2019.11.023
  • Zubcevic Lejla, Hsu Allen L, Borgnia Mario J, Lee Seok-Yong. 2019. Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. eLife, 8. https://doi.org/10.7554/elife.45779
  • Zubcevic Lejla, Borschel William F, Hsu Allen L, Borgnia Mario J, Lee Seok-Yong. 2019. Regulatory switch at the cytoplasmic interface controls TRPV channel gating. eLife, 8. https://doi.org/10.7554/elife.47746
  • Zubcevic Lejla, Le Son, Yang Huanghe, Lee Seok-Yong. 2018. Conformational plasticity in the selectivity filter of the TRPV2 ion channel. Nature Structural & Molecular Biology, 25 (5), 405-415. https://doi.org/10.1038/s41594-018-0059-z
  • Zubcevic Lejla, Herzik Mark A, Wu Mengyu, Borschel William F, Hirschi Marscha, Song Albert, Lander Gabriel C, Lee Seok-Yong. 2019. Conformational Ensemble of the Human TRPV3 Ion Channel. Biophysical Journal, 116 (3), 536a. https://doi.org/10.1016/j.bpj.2018.11.2886
  • Yin Ying, Wu Mengyu, Zubcevic Lejla, Borschel William F, Lander Gabriel C, Lee Seok-Yong. 2018. Structure of the cold- and menthol-sensing ion channel TRPM8. Science, 359 (6372), 237-241. https://doi.org/10.1126/science.aan4325
  • Zubcevic Lejla, Herzik Mark A, Chung Ben C, Liu Zhirui, Lander Gabriel C, Lee Seok-Yong. 2016. Cryo-electron microscopy structure of the TRPV2 ion channel. Nature Structural & Molecular Biology, 23 (2), 180-186. https://doi.org/10.1038/nsmb.3159