Ken L. Seldeen, Ph.D.

Professional Background

My goal is to investigate and implement sustainable strategies for successful aging that maintain and even enhance functional capacity, independence, and quality of life throughout aging. My expertise involves translational approaches that span the lab to the living room, including human‑relevant animal modeling of frailty, exercise, physical performance as well as muscle biology, histological analysis, metabolism and mitochondrial function. More recently my efforts include the full translation of our animal studies as the principal investigator of a 4‑year VA RR&D-funded clinical trial to establish the efficacy of nicotinamide riboside (a form of vitamin B3) supplementation for functional capacity in older Veterans. At present, tens of millions of Americans are at or above 65 years of age and growing – presenting significant challenges to our healthcare systems. Therefore my research program is very well positioned to meet the growing demands for healthy living strategies that will ensure greater numbers of the population can engage in successful aging.

• BS, Biology, California Lutheran University, Thousand Oaks, CA
• PhD, Biochemistry and Molecular Biology, University of Miami, Miami, FL
• Post Doctoral Fellowship, Biochemistry and Molecular Biology, University of Miami, Miami, FL
• Post Doctoral Fellowship, Geriatrics, University of Miami / Miami VAHS, Miami, FL
• Post Doctoral Fellowship, Geriatrics, University at Buffalo / VA Western New York, Buffalo, NY

• Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans, VA Rehabilitation Research and Development, PI

• Seldeen KL, Troen BR. 2021. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?. Advances in geriatric medicine and research, 3 (2)
• Seldeen KL, Shahini A, Thiyagarajan R, Redae Y, Leiker M, Rajabian N, Dynka A, Andreadis ST, Troen BR. 2021. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors.. Nutrition (Burbank, Los Angeles County, Calif.), 87-88, 111189
• Seldeen KL, Thiyagarajan R, Redae Y, Jacob A, Troen BR, Quigg RJ, Alexander JJ. 2020. Absence of complement factor H reduces physical performance in C57BL6 mice.. Immunobiology, 225 (5), 152003
• Seldeen KL, Berman RN, Pang M, Lasky G, Weiss C, MacDonald BA, Thiyagarajan R, Redae Y, Troen BR. 2020. Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.. Nutrients, 12 (10)
• Colón-Emeric C, Whitson HE, Berry SD, Fielding RA, Houston DK, Kiel DP, Rosen CJ, Seldeen KL, Volpi E, White JP, Troen BR. 2020. AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders.. Journal of the American Geriatrics Society, 68 (1), 31-38
• Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. 2019. Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice.. Journal of visualized experiments : JoVE (144)
• Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. 2019. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools.. Mechanisms of ageing and development, 180, 49-62
• Pang M, Rodríguez-Gonzalez M, Hernandez M, Recinos CC, Seldeen KL, Troen BR. 2019. AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors.. Journal of cellular biochemistry, 120 (8), 12382-12392