Joel D. Mermis, M.D.

Professional Background

Dr. Joel Mermis is a professor of medicine and director of the adult cystic fibrosis program at the University of Kansas Medical Center. Dr. Mermis is principal investigator of the Cystic Fibrosis Foundation supported University of Kansas Medical Center Therapeutic Development Center.

Dr. Mermis received a medical degree from the University of Kansas, completed internal medicine residency and chief residency at Emory University in Atlanta, Georgia, and pulmonary and critical care fellowship from the University of Kansas Medical Center.

Dr. Mermis is the recipient of several Cystic Fibrosis Foundation grants and is the principal investigator of ongoing observational and therapeutic clinical trials with focus on cystic fibrosis and bronchiectasis.

• BS, Biochemistry, University of Kansas, Lawrence, Kansas
• MD, Medicine, The University of Kansas Medical Center, Kansas City, Kansas
• Residency, Internal Medicine, Emory University
• Other, Internal Medicine, Emory University, Atlanta , Georgia
• Clinical Fellowship, Pulmonary and Critical Care, University of Kansas Medical Center

• Dept. of Internal Medicine Research Committee, University of Kansas Medical Center Dept. of Internal Medicine Research Committee, Member, 2021 - Present
• American College of Chest Physicians, Member, 2010 - Present
• American Thoracic Society, Member, 2010 - Present
• Cystic Fibrosis Foundation, Member, 2010 - Present

• An Open-label, Phase 1/2 Trial of Gene Therapy 4D-710 in Adults with Cystic Fibrosis, 4D Molecular Therapeutics, PI
• Colorectal Cancer Screening in Cystic Fibrosis (NICE-CF), Cystic Fibrosis Foundation, Site-PI
• MAYFLOWERS study (A Prospective Study Evaluating Maternal and Fetal Outcomes in the Era of Modulators), Cystic Fibrosis Foundation, Site-PI
• Therapeutics Development Network Center Award, Cystic Fibrosis Foundation, PI
• A Phase 3, Open-label Study Evaluating the Long Term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis, Vertex Pharmaceuticals, PI

• Komakula S, Mermis J, Khatri S, Savill S, Haque S, Jackson AC, Holguin F. 2006. Relationship of body mass index with airway mechanics and adipocyte-related cytokines in African American asthmatics.. JOURNAL OF INVESTIGATIVE MEDICINE, 54 (1), S296-S296
• Komakula Sushma, Khatri Sumita, Mermis Joel, Savill Samira, Haque Shireen, Rojas Mauricio, Brown LouAnn, Teague Gerald W, Holguin Fernando. 2007. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. RESPIRATORY RESEARCH, 8
• Mermis Joel, O'Brien-Ladner Amy, Dhillon Navneet. 2010. HIV-Tat Potentiates The Proliferation Of Vascular Smooth Muscle Cells Through Induction Of PDGF/ PDGF- Receptor Axis. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1176
• Mermis Joel, O'Brien-Ladner Amy, Dhillon Navneet K. 2011. HIV-Associated Viral Proteins Induce Parallel Hypoxia-Inducible Factor-1Alpha And Platelet Derived Growth Factor Accumulation. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5014
• Mermis Joel, Pornputtapitak Warangkana, O'Brien-Ladner Amy, El-Gendy N., Dhillon Navneet K, Berkland Cory. 2011. Nanocluster Formulations Of Budesonide Enhance Aerosol Delivery Through Endotracheal Tubes. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2145
• Lovitt Collin, Mermis Joel. 2011. Diffuse Alveolar Hemorrhage as a Complication of Churg Strauss. Kansas Journal of Medicine, 4 (3). http://dx.doi.org/10.17161/kjm.v4i3.11363
• Mermis Joel, Gu Haihua, Xue Bing, Li Fang, Tawfik Ossama, Buch Shilpa, Bartolome Sonja, O'Brien-Ladner Amy, Dhillon Navneet K. 2011. Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling. Respiratory Research, 12 (1). http://dx.doi.org/10.1186/1465-9921-12-103
• Strom Jeremy C, Simpson Steven Q, Stites Steven, Mermis Joel. 2012. Incidence Of Symptomatic Venous Thromboembolism Associated With Peripherally Inserted Central Catheters In Patients With Cystic Fibrosis. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2813
• Burnett David M, Barry Ashley N, Mermis Joel D. 2020. Physical Activity Level and Perception of Exercise in Cystic Fibrosis. RESPIRATORY CARE, 65 (4), 500-506
• Mahmood Uzair Ahmed, Mermis Joel D, Khan Noor-Mah, El Atrouni Wissam. 2021. Rhabdomyolysis With COVID-19. Infectious Diseases in Clinical Practice, 29 (2), e129-e130. http://dx.doi.org/10.1097/ipc.0000000000000968