Daniel Parente, M.D., Ph.D.

Professional Background

Dr. Daniel Parente is an Associate Professor of Family Medicine and Community Health. He is a board-certified physician in Family Medicine. Dr. Parente’s main clinical role is the care of hospitalized persons. His research program is centered around improving the precision of medicine in primary care. Dr. Parente also serves as the Research Director for the Family Medicine Residency Program.

• BS, Electrical Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
• BS, Engineering Physics, University of Illinois at Urbana-Champaign, Urbana, IL
• BS, Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL
• MD/PhD, Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansa City, Kansas
• Residency, Family Medicine, University of Kansas Medical Center, Kansas City, Kansas

• Board Certification, American Board of Family Medicine
• Kansas Medical License, Kansas Board of Healing Arts
• Missouri Medical License, Missouri Division of Professional Registration

• Society of Teachers for Family Medicine Research Committee, Member, 2023 - Present
• American Academy of Family Physicians, American Academy of Family Physicians, Member, 2016 - Present
• Kansas Academy of Family Physicians, Kansas Academy of Family Physicians, Member, 2016 - Present

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Research

Overview

Dr. Parente’s research is centered around improving precision medicine in primary care. His research focuses primarily on how advanced technologies – such as machine learning or genomic technologies – can be used to improve patient outcomes. Additionally, multidisciplinary teams are needed to understand the clinical impact of novel or rare monogenic diseases. Dr. Parente has used exome sequencing to describe monogenic pathology in neurodevelopment. Finally, understanding the fundamental rules that constrain protein evolution is crucial for interpreting variants observed in patient genomes. Our interdisciplinary teams have used several model systems to interrogate these fundamental rules.

If you would like to collaborate on topics within precision medicine, genomic medicine, preventive care or understanding the evolutionary architecture of protein function, Dr. Parente would love to hear from you. Please contact him at dparente@kumc.edu.

• Parente Daniel J, Ojo Akinlolu, Gurley Tami, LeMaster Joseph W, Wild David M, Mustafa Reem A. 2021. Acceptance of COVID-19 vaccination among healthcare personnel. J AM Board Family Medicine, 34 (3), 498-508
• Parente Daniel J. 2020. PolyBoost: An enhanced genomic variant classifier using extreme gradient boosting. Proteomics: Clinical Applications, 15 (2-3), e1900124
• Parente DJ. 2020. BRCA-Related Cancer Genetic Counseling is Indicated in Many Women Seeking Primary Care.. Journal of the American Board of Family Medicine : JABFM, 33 (6), 885-893
• Parente DJ, Morris SM, McKinstry RC, Brandt T, Gabau E, Ruiz A, Shinawi M. 2020. Sorting nexin 27 (SNX27) variants associated with seizures, developmental delay, behavioral disturbance, and subcortical brain abnormalities.. Clinical genetics, 97 (3), 437-446
• Martin TA, Wu T, Tang Q, Dougherty LL, Parente DJ, Swint-Kruse L, Fenton AW. 2020. Identification of biochemically neutral positions in liver pyruvate kinase.. Proteins, 88 (10), 1340-1350
• Parente DJ, Garriga C, Baskin B, Douglas G, Cho MT, Araujo GC, Shinawi M. 2017. Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity.. American journal of medical genetics. Part A, 173 (1), 213-216
• Sousa FL, Parente DJ, Shis DL, Hessman JA, Chazelle A, Bennett MR, Teichmann SA, Swint-Kruse L. 2016. AlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription Regulators.. Journal of molecular biology, 428 (4), 671-678
• Parente DJ, Ray JC, Swint-Kruse L. 2015. Amino acid positions subject to multiple coevolutionary constraints can be robustly identified by their eigenvector network centrality scores.. Proteins, 83 (12), 2293-306
• Parente DJ, Swint-Kruse L. 2013. Multiple co-evolutionary networks are supported by the common tertiary scaffold of the LacI/GalR proteins.. PloS one, 8 (12), e84398
• Tungtur S, Parente DJ, Swint-Kruse L. 2011. Functionally important positions can comprise the majority of a protein's architecture.. Proteins, 79 (5), 1589-608