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Long Zheng Laboratory

Publications

X. Long Zheng, MD, PhD

Selected Publications

  1. Cao WJ, Basu MK, Staley E, Zheng XL. Genetic variants contribute to modulation of renal function in patients with immune thrombotic thrombocytopenic purpura. Blood VTH, 2024 Jul 16;1(4):100019. doi:10.1016/j.bvth.2024.100019 PMID:40765928.
  2. Sarani N, Dasgupta A, Enders M, Rowan L, Elsarraj H, Gralnek S, Shay M, Lemar LR, Simpson SQ, Cunningham MT, Zheng XL.Clinical utility of recently FDA-approved IntelliSep test (Sepsis biomarker) for early diagnosis of sepsis: Comparison with other biomarkers. J Clin Med. 2024 Aug 16;13(16):4852. doi:10.3390/jcm13164852. PMID: 39200994.
  3. Halkidis K, Meng C, Pillai VG, Shay M, Liu S, Zheng XL. Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura. Res. Pract. Thromb. Haemost. 2024 Oct 23;8(7):102603. doi:10.1016/j.rpth.2024.102603. PMID: 39624585.
  4. Roytenberg R, Yue H, DeHart A, Kim E, Bai F, Kim Y, Denning K, Kwei A, Zhang Q, Liu J, Zheng XL, Li W. Thymidine phosphorylase mediates SARS-CoV-2 spike protein enhanced thrombosis in K18-hACE2TG mice. Thromb Res. 2024 Dec;244:109195. doi:10.1016/j.thromres.2024.109195. PMID: 39442286.
  5. Hogan K, Mudunkotuwa G, Phadnis M, Zheng XL, Ye Z. ABO incompatibility and component irradiation are independently associated with platelet transfusion reaction rate. Transfusion. 2025 Mar;65(3):496-504. doi:10.1111/trf.18130. PMID: 39806986. 
  6. Fatola A, Evans MD, Brown J, Davis E, Johnson A, Antun AG, Farland AM, Woods R, Metjian A, Park YA, de Ridder G, Gibson B, Kasthuri RS, Liles DK, Eubanks S, Akwaa F, Clover T, Kreuziger LB, Sadler JE, Sridharan M, Go RS, McCrae KR, Upreti HV, Lim MY, Kocher NK, Gangaraju R, Zheng XL, Raval JS, Masias C, Cataland SR, Mazepa M, Chaturvedi S. Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era. Blood Adv. 2025 Jan 28;9(2):417-424. doi:10.1182/bloodadvances.2024013313. PMID: 39626301.
  7. Cao W, Liu Y, Zhang XF, Zheng XL. A mutant complement factor H (W1183R) enhances proteolytic cleavage of von Willebrand factor by ADAMTS-13 under shear. J. Thromb. Haemost. 2025 Apr;23(4):1229-1240. doi:10.1016/j.jtha.2024.11.031. PMID: 39798927.
  8. Nelson M, Dasgupta A, Zheng XL. Clinical evaluation of the heparin therapeutic window using activated clotting time within neurological interventional radiology at an academic medical center. Arch. Pathol. Lab. Med. 2025 Oct 1;149(10):938-943. doi:10.5858/arpa.2024-0399-OA. PMID: 40059040.
  9. Liu S, Ma M, Qu J, Muia J, Wu Z, Bonnez Q, Vanhoorelbeke K, Zheng L, Zhao X, Zheng XL. Arginine methylation by PRMT1 affects ADAMTS13 secretion and enzymatic activity. Arterioscler Thromb Vasc Biol. 2025 Apr;45(4):506-522. doi:10.1161/ATVBAHA.124.322249. PMID: 39945068. 
  10. Zheng L, Adili R, Wu Z, Zhang Q, Zhu G, Lei X, Liu Z, Neves MAD, Ma W, Slavkovic S, Xu XR, Ni H, Zheng XL. Preventative and therapeutic effects of a novel humanized anti-GPIb alpha fab fragment in a murine model of thrombotic thrombocytopenic purpura. J. Thromb. Haemost. 2025 May;23(5):1596-1607. doi:10.1016/j.jtha.2025.02.009. PMID: 39956431.
  11. Zheng L, Wu Z, Yada N, Liu S, Lin C, Bignotti A, Zhao X, Zheng XL. Modeling ANKRD26 5'-UTR mutation-related thrombocytopenia in zebrafish. Dis Model Mech. 2025 Apr 1:dmm.052222. doi:10.1242/dmm.052222. PMID: 40170493.
  12. Coppo P, Bubenheim M, Benhamou Y, Völker L, Brinkkötter P, Kühne L, Knöbl P, Michiganngot-Castellano ME, Pascual-Izquierdo C, de la Rubia J, Del Rio Garma J, Chaturvedi S, Masias C, Mazepa M, Zheng XL, Sinkovits G, Réti M, Patriquin CJ, Pavenski K, Boechat T, Farias J, Oliveira Ribeiro EF, Lobo de Andrade ML, Veyradier A, Joly BS, Bouzid R, Sakai K, Matsumoto M, Agosti P, Mancini I, Peyvandi F, Georgiavriilaki E, Stubbs M, Hmaid A, Cataland S, Lämmle B, Scully M. Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective cohort study (The Capla 1000+ project). eClinicalMedicine. 2025 Mar 30;82:103168. doi:10.1016/j.eclinm.2025.103168. PMID: 40235949.
  13. Zhang Q, Huang X, Lee H, Lee JG, Liu S, Limbu S, Basu MK, D’Agnillo F, Han Z, and Zheng XL. SARS-CoV-2 ORF7a activates endothelium to synthesize and secrete von Willebrand factor that promotes thrombosis. Res Pract Thromb Haemost, 2025 Jun 20;9(4):102947. doi:10.1016/j.rpth.2025.102947 PMID: 40697485. 
  14. Azoulay E, Veyradier A, Caland S, Joly BS, Knoebl P, Zafrani L, Wendon J, Fakhouri F, Lämmle B, Pavenski K, Biebuyck N, Vanhoorelbeke K, Chaturvedi S, Pishko AM, Donadello K, Scully M, Matsumoto M, Peyvandi F, Michiganngot-Castellano ME, Zheng XL, Mariotte E, Benhamou Y, Coppo P. Thrombotic thrombocytopenic purpura: Early diagnosis and effective treatment in 2025. Intensive Care Med. 2025 Sep;51(9):1744-1746. doi:10.1007/s00134-025-08041-6. PMID: 40694082. 
  15. Zheng XL, et al. 2025 Focused update of the ISTH guidelines for diagnosis and management of TTP.  J. Thromb. Haemost, 2025 Jun 17:S1538-7836(25)00360-5. doi:10.1016/j.jtha.2025.06.002. PMID: 40533296.
  16. Zheng XL. Restoring VWF multimerization via endothelial gene therapy: A minimalist yet mechanistically precise approach.Mol Ther. 2025 Dec 3;33(12):5936-5937. doi:10.1016/j.ymthe.2025.10.064. PMID: 41240902.
  17. Li Z, Zhao P, Fu H, Wang C, He Y, Zhu X, Huang Q, Wu J, Zhang Y, Wang F, Han W, Yan C, Wang Z, Kong J, Han T, Wang J, Chen Y, Lv M, Sun Y, Chen Y, Mo X, Zhao X, Wang Y, Chang Y, Xu L, Zheng XL*, Huang X*, Zhang X*. Thrombotic thrombocytopenic purpura following allogeneic hematopoietic stem cell transplantation: a rare but fatal complication. J Thromb Haemost, 2026 Mar;24(3):1067-1078.  doi: 10.1016/j.jtha.2025.11.015. PMID: 41390106 (*corresponding authors)
  18. Walkenhorst M, Basu MK, Cui W, Kumar M, Vallurupalli A, Sitek A, Zhao X, Zheng XL, Zhang D. Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings. Front Med (Lausanne), 2025:12:1679484.  doi: 10.3389/fmed.2025.1679484. PMID: 41488087, PMCID: PMC12756459.
  19. Ye Z, Sami F, Hinojosa O, Zheng L, Gu H, Zhao X, Dasgupta A, and Zheng XL. Assessing Bleeding Risk by Thromboelastography When Automated Platelet Count Fails due to Giant Platelets. Blood VTH, 2026, Feb 21, 100153. https://doi.org/10.1016/j.bvth.2026.100153.
  20. Zhang Q, Zheng L, Wu Z, Chai Z, Dominguez E, Soares M, and Zheng XL. Rat Models of Thrombotic Thrombocytopenic Purpura Reveal Crucial Role of Placental ADAMTS13 in Perinatal Survival. Blood Adv. 2026 Mar 31: bloodadvances.2026019661. doi: 10.1182/bloodadvances.2026019661. PMID: 41915891
  21. Liu S, Dong X, Bonnez Q, Chai Z, Meng C, Gil1M, Vanhoorelbeke K, Halkidis K, and Zheng XL.  ADAMTS13 R1206K Variant Exhibits an Open Conformation and Enhanced Proteolytic Activity toward von Willebrand factor. J Thromb Haemost, 2026, Mar 25:S1538-7836(26)00199-6. doi: 10.1016/j.jtha.2026.03.010. PMID: 41895527
  22. Meng C, Halkidis K, Gil M, Liu S, and Zheng XL. Human monoclonal and polyclonal anti-ADAMTS13 antibodies in immune thrombotic thrombocytopenic purpura: variable mechanisms of inhibition. J Thromb Haemost. 2026 Aug;24(8):3017-3029. PMID: 42190881.
  23. Dong H, Mao Y, Zheng XL. A Paradoxical Role of ADAMTS13: Enhancing Collagen-Induced Platelet Aggregation and Activation via AKT Phosphorylation. Thromb Haemost, 2026 Jun 19:10.1055/a-2892-7205.  doi: 10.1055/a-2892-7205. Ahead of publication. PMID: 42269700.

PUBMED PUBLICATIONS

KU School of Medicine

University of Kansas Medical Center
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