At the Kharel Lab, we are fascinated by the dynamic structural and functional landscape of RNA and how it shapes cellular biology. While we explore diverse aspects of RNA biology, our current focus is on investigating unique RNA structures called G‑quadruplexes. Using an integrated toolkit of biochemical, biophysical, cellular, genomic, and computational approaches, we aim to uncover their roles in health and disease. Our long‑term goal is to reveal fundamental RNA‑centric pathogenic mechanisms and help pave the way for new RNA‑targeted therapies.