Cardiac and Cardiothoracic Research
Cardiac and Cardiothoracic Clinical Studies
| Study Title and PI | Funding Source | ClinicalTrials.gov Number (if applicable) | Brief Summary |
|---|---|---|---|
| Reversing glucose and lipid-mediated vascular dysfunction (REGAL) PI: Seth Holwerda |
Investigator Initiated | NCT04832009 | The purpose of this study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure. Hypertension, obesity, and insulin resistance are associated with elevated muscle sympathetic nerve activity (MSNA), which is important for blood pressure regulation. |
| Sympathetic-vascular dysfunction in obesity and insulin resistance (Vit C study) PI: Seth Holwerda |
Investigator Initiated | NCT04715022 | The broad research goal of this study is to examine and understand the development of hypertension in obesity and insulin resistance. |
Recent Publications
Effect of Preoperative Cannabis Use on Postoperative Pain and Outcomes Following Cardiothoracic Surgery
Shah S, Fletcher P, Hamadah K, Gilmore D, Staples B, Chadwick A, He J, Kim J, Flynn B. Semin Cardiothorac Vasc Anesth. 2025. Online ahead of print
Outcomes of Patients Requiring VA-ECMO for Cardiogenic Shock and Evaluation of Programmatic Changes
Kidd B, Hughes K, Zorn T, He J, Kim J, Whisenhunt M, Flynn B. J Cardiothorac Vasc Anesth. 2025;39(8):2095-2101.
WATCHMAN Gone Astray, Catastrophic Mitral Regurgitation Following Device Dislodgement
Jouryyeh B, Beshara M. Ann Card Anaesth. 2025;28(3):313-316.