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Past Interstitial Lung Disease (ILD) and Sarcoidosis Trials

Years NCT Number

Study Title

Principle Investigator

Sponsor

2012 -2014 NCT01366209

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Efficacy and Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Mark Hamblin

Intermune, Inc.

2013 - 2015 NCT00662038

An Open-Label Extension Study of the Long-Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (IPF)

Mark Hamblin

Intermune, Inc.

2013 - 2018 NCT01890265

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of FG-3019 in Patients with Idiopathic Pulmonary Fibrosis

Mark Hamblin

Fibrogen, Inc.

2013 - 2018 NCT01872689

A Phase II, Randomized, Double-Blind, Placebo-Controlled, Study to Assess the Efficacy and Safety of Lebrikizumab in Patients with Idiopathic Pulmonary Fibrosis

Mark Hamblin

Genentech-Roche, Inc.

2014 - 2017 NCT01371305

Randomized, Double-Blind, Placebo-Controlled,Multiple Dose, Dose-Escalation Study of STX-100 in Patients with Idiopathic Pulmonary Fibrosis (IPF)

Mark Hamblin

Biogen MA Inc.

2014 - 2015 NCT02141087

A Treatment Protocol to Allow Patients in the US with Idiopathic Pulmonary Fibrosis Access to Pirfenidone

Mark Hamblin

Intermune, Inc.

2016 - 2019 NCT02550873

A Phase 2 Trial to Evaluate the Efficacy of PRM-151 in Subjects with Idiopathic Pulmonary Fibrosis (IPF)

Mark Hamblin

Promedior, Inc.

2016 - 2019 NCT02597933

A double blind, randomised, placebo-controlled trial evaluating efficacy and safety of oral nintedanib treatment for at least 52 weeks in patients with Systemic Sclerosis associated Interstitial Lung Disease(SSc-ILD).

Mark Hamblin

Boehringer Ingelheim 

2016 - 2018 NCT02846324

A Phase II randomized, double-blind, placebo-controlled study of GBT440 to evaluate the safety, tolerability, pharmacokinetics and effect on hypoxemia in subjects with Idiopathic Pulmonary Fibrosis (IPF)

Mark Hamblin

Global Blood Therapeutics

2016 - 2023 NCT02758808

PFF Patient Registry Protocol

Mark Hamblin

University of Michigan 

2017 - 2018 NCT02802345

A 24-week, double-blind, randomized, parallel-group study evaluating the efficacy and safety of oral nintedanib coadministered with oral sildenafil, compared to treatment with nintedanib alone, in patients with idiopathic pulmonary fibrosis (IPF) and advanced lung function impairment

Lucas Pitts

Boehringer Ingelheim 

2017 - 2019 NCT02999178

A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of nintedanib over 52 weeks in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

Lucas Pitts

Boehringer Ingelheim 

2018 - 2021 NCT03313180

An open-label extension trial to assess the long term safety of nintedanib in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SSc-ILD) SENSCIS-ON

Mark Hamblin

Boehringer Ingelheim 

2018 - 2020 NCT03573505

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of BG00011 in Patients With Idiopathic Pulmonary Fibrosis

Mark Hamblin

Biogen MA Inc.

2018 - 2021 NCT02759120

Study of Clinical Efficacy of Antimicrobial Therapy Strategy Using Pragmatic Design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF)

Mark Hamblin

NIH/NHLBI

2018 - 2022 NCT03320070

A Phase 5 Multicenter, Randomized, Double Blind, Placebo-Controlled Pilot Study to Assess the Efficacy and Safety of H.P. Acthar Gel in Subjects with Pulmonary Sarcoidosis

Mark Hamblin

Mallinckrodt Pharmaceuticals

2019 - 2021 NCT03711162

A Phase 3, randomized, double-blind, parallel-group, placebo-controlled multi-center study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis

Mark Hamblin

Galapagos

2019 - 2021 NCT03820726

An open-label extension trial of the long-term safety of nintedanib in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

Lucas Pitts

Fibrogen, Inc.

2020 - 2022 NCT04419506

A Randomised, Double-blind, Placebo-controlled Parallel Group Study in IPF Patients Over 12 Weeks Evaluating Efficacy, Safety and Tolerability of BI 1015550 Taken Orally

Mark Hamblin

Boehringer Ingelheim

KU School of Medicine

University of Kansas Medical Center
Department of Internal Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
Mailstop 3007
3901 Rainbow Boulevard
Kansas City, KS 66160
Phone: 913-588-6045