Aria
Sabbagh
Medical Student
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<p><span>Aria is a KINBRE scholarship recipient (April 2014 - May 2015) enrolled in pre-medicine, currently on a research rotation. The purpose of Aria's project is to determine the role of nuclear BCL9 in DCIS invasive progression. He is working on finding the nuclear localization signal of BCL9 in order to delete this sequence using CRISPR genomic editing. By deleting the nuclear localization signal, he will be able to determine the cytoplasmic functions of BCL9 in mouse xenograft models of DCIS. The hypothesis is that if BCL9 is blocked from entering the nucleus, then proliferation, invasion, and angiogenesis will be significantly decreased in DCIS xenograft models.</span></p>